塞来昔布脂质体鼻凝胶抑制tau蛋白磷酸化及其“类朊蛋白样”传播的分子机制研究

81500934
2015
H0902.意识障碍与认知功能障碍
关佩沛
青年科学基金项目
副教授
东北大学
18万元
塞来昔布;脂质体鼻凝胶;蛋白质传播;阿尔茨海默病;tau蛋白磷酸化
2016-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Transferrin is responsible for mediating the effects of iron ions on the regulation of anterior pharynx-defective-1alpha/beta and Presenilin 1 expression via PGE2 and PGD2 at the early stage of Alzheimer's Disease. 期刊论文 Lu Chen-Di;Ma Ji-Kang;Luo Zheng-Yang;Tai Qun-Xi;Wang Pu;Guan Pei-Pei
2 The roles of prostaglandin F2 in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes. 期刊论文 Guan Pei-Pei;Ding Wei-Yan;Wang Pu
3 Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor alpha and the Activity of gamma-Secretase in a beta-Amyloid Protein-Dependent Mechanism in APP/PS1 Transgenic Mice. 期刊论文 Yu Xin;Guan Pei-Pei;Zhu Di;Liang Yun-Yue;Wang Tao;Wang Zhan-You;Wang Pu
4 Prostaglandin I2 is responsible for ameliorating prostaglandin E2 stress in stimulating the expression of tumor necrosis factor alpha in a beta-amyloid protein -dependent mechanism. 期刊论文 Zheng Shao-Qin;Gong Zi-Yi;Lu Chen-Di;Wang Pu
5 Structures and biological activities of the triterpenoids and sesquiterpenoids from Alisma orientale 期刊论文 Ma Qingjuan;Han Li;Bi Xiaoxu;Wang Xingbo;Mu Yu;Guan Peipei;Li Liya;Huang Xueshi
6 Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease. 期刊论文 Wang Pu;Wang Zhan-You
7 Anti-Inflammatory Activities and Liver Protection of Alisol F and 25-Anhydroalisol F through the Inhibition of MAPK, STAT3, and NF-kappaB Activation In Vitro and In Vivo. 期刊论文 Bi Xiaoxu;Wang Pu;Ma Qingjuan;Han Li;Wang Xingbo;Mu Yu;Guan Peipei;Qu Xiaodan;Wang Zhanyou;Huang Xueshi
8 Readily restoring freeze-dried probilosomes as potential nanocarriers for enhancing oral delivery of cyclosporine A. 期刊论文 Guan Peipei;Lu Yi;Qi Jianping;Wu Wei
9 Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1alpha and anterior pharynx-defective-1beta in amyloid precursor protein/presenilin 1 transgenic mice. 期刊论文 Wang Pu;Guan Pei-Pei;Guo Jing-Wen;Cao Long-Long;Xu Guo-Biao;Yu Xin;Wang Yue;Wang Zhan-You
10 Effect of borrelidin on hepatocellular carcinoma cells in vitro and in vivo 期刊论文 Gao Xiaoxiao;Jiang Yi;Han Li;Chen Xiu;Hu Caijuan;Su Hao;Mu Yu;Guan Peipei;Huang Xueshi
11 一种脑靶向的塞来昔布量子点脂质体混悬液及其制备方法 专利 王璞;郭静文;关佩沛;王占友
12 Anti-Inflammatory Effects, SAR, and Action Mechanism of Monoterpenoids from Radix Paeoniae Alba on LPS-Stimulated RAW 264.7 Cells. 期刊论文 Bi Xiaoxu;Han Li;Qu Tiange;Mu Yu;Guan Peipei;Qu Xiaodan;Wang Zhanyou;Huang Xueshi
13 Integrated communications between cyclooxygenase-2 and Alzheimer's disease. 期刊论文 Guan Pei-Pei;Wang Pu
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